Every Cell Has A Sex By Dr. Paula A. Johnson, MD, MPH
It doesn’t take a medical degree to know that men and
women are different; but it will take sex-specific research to better understand
how cellular and molecular differences in males and females affect every aspect
of our health. The phrase “every cell has a sex”, coined by the Institute of
Medicine, captures the essence of how fundamentally different men and women are
when it comes to our health.
Our cells, the very building blocks of our existence, are
infused with differences that cannot be ignored when we study the prevention,
detection and treatment of disease. From cardiovascular disease to lung cancer
to Alzheimer’s disease to depression, men and women’s experience of disease is
distinct. Yet every day in this country,
we ignore these important health differences by funding and conducting medical
research that is flawed because it fails to recognize sex differences. This
failure is both an equal rights issue as well as an issue of the quality and
integrity of science and medicine.
Twenty years ago this year, a bipartisan group of legislators
working with a multi-stakeholder movement of patients, providers, policymakers
and advocates, shone a spotlight on this issue. The result was the passage of
the 1993 National Institutes of Health (NIH) Revitalization Act, a law
mandating that women and minorities be included in clinical trials funded by
the NIH. In many ways the law has been a
success. Since its passage, women have been routinely included in clinical
trials and we have learned how certain diseases, such as cardiovascular
disease, present differently in men and women.
Yet major inequities persist as we leave women’s health to chance by
ignoring important, but mainly invisible, sex differences in health.
Women are still not included in
clinical research in numbers reflecting the prevalence and impact of disease in
women. This means that clinical practices including treatment guidelines and
medication dosages are derived largely from the male physiological
perspective. Even at the very early
stages of scientific discovery, a gender lens is not considered as there
remains a strong bias in research studies to use male animals to study
treatments for disease.
Why are we willing to leave women’s health to chance? Why
are women who never smoked being diagnosed with lung cancer, at rates three
times that of men who are non-smokers? Even though cardiovascular disease is
the leading cause of death for women in the United States, why are we satisfied
with statistics that show only one-third of cardiovascular clinical trial
subjects are female? In an age of
cutting edge technology and expansive sources of research data, why is it acceptable
that women are 70% more likely than men to suffer from depression and we don’t
know why?
The fact is we
remain complacent about biomedical research even though two-thirds of the 5.1
million people suffering from Alzheimer’s disease are women and our failure to
look at sex differences leaves us wondering why. We accept
pre-clinical research that all too often does not include female animals and we
accept clinical trials that do not always adequately include women and do not
consistently report the results in a way that allows us to understand the
impact of these treatments on women.
Two decades after the historic NIH Revitalization Act, we
are on the verge of being able to dramatically improve the health of women. We know that when we apply a gender lens to
science and practice, lives are saved.
We know that when we invest in women’s health research and in
understanding how women and men’s health differ, breakthroughs can occur.
It is the right time to increase awareness of the gender
inequities in scientific research and health care and for organizations that
focus on the health of women to join forces to demand change. We have the
ability to ensure that the next 20 years brings breakthrough discoveries as to
why sex differences occur and to use that knowledge to improve the health of
women for this generation and for generations to come.
Dr. Paula A. Johnson, MD, MPH
Executive Director, Connors Center for Women’s Health at
Brigham and Women’s Hospital and Professor of Medicine Harvard Medical School
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